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High Lipoprotein(a) levels in type 1 diabetes linked to cardiovascular disease

High blood levels of the lipid lipoprotein(a) in people with type 1 diabetes add to the already elevated risk of developing cardiovascular disease, researchers from Karolinska Institutet in Sweden report in a paper published in the prestigious journal Diabetes Care.

Lipoprotein(a) levels should therefore be measured in patients with type 1 diabetes and form part of the total risk assessment, say the researchers.

“There is currently no readily available treatment for high lipoprotein(a) levels, but the treatment of all other risk factors for cardiovascular disease should be optimised for patients with type 1 diabetes and high levels of lipoprotein(a),” says the study’s lead author Karin Littmann, Ph.D. student at the Department of Laboratory Medicine at Karolinska Institutet.

As a consequence of their disease, patients with type 1 diabetes run a higher risk of developing cardiovascular disease. Diabetes and high blood-sugar levels can also eventually cause the leakage of proteins into the urine, reduced kidney function, impaired circulation and retinal damage, leading to impaired vision.

Lipoprotein(a) is a type of blood fat, the levels of which are determined mostly by hereditary factors rather than diet or lifestyle, like other blood lipids. Previous research has shown that high levels of lipoprotein(a) entail a higher risk of cardiovascular diseases, such as myocardial infarction, stroke and calcified aortic valve disease.

Findings show that patients with type 1 diabetes and high lipoprotein(a) levels had a 50 per cent higher risk of developing some form of cardiovascular disease, a 70 per cent higher risk of coronary artery disease and a 100 per cent higher risk of calcified aortic valve disease, than patients with type 1 diabetes and low lipoprotein(a) levels.

“Our conclusion is that high levels of lipoprotein(a) in patients with type 1 diabetes add to the already elevated risk of developing cardiovascular disease,” says Dr. Littmann.

More information: Karin Littmann et al. The association of lipoprotein(a) plasma levels with prevalence of cardiovascular disease and metabolic control status in patients with type 1 diabetes mellitus. Diabetes Care, online 18 December 2019, DOI: 10.2337/DC19-1398.

Provided by Karolinska Institutet

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